SLC45A1

Entrez Summary: This gene was isolated initially from a region on chromosome 1p that is frequently deleted in human neuroblastoma, although no causal relationship has since been demonstrated. The encoded protein belongs to the glycoside-pentoside-hexuronide cation symporter transporter family and may play a role in glucose uptake. [provided by RefSeq, Mar 2014].
UniProt Summary: Proton-associated glucose transporter in the brain. {ECO:0000250|UniProtKB:Q8K4S3, ECO:0000269|PubMed:28434495}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CAY10603 0.55μM R08 exp467	-1.81
Nutlin-3A 1.6μM R06 exp294	1.88

disaccharide transport
oligosaccharide transport
sucrose transport
sucrose:proton symporter activity
glucose transmembrane transport
hexose transmembrane transport
monosaccharide transmembrane transport
carbohydrate transmembrane transport
carbohydrate transport
transmembrane transport
membrane