SLC5A1
Gene Information
- Official Symbol: SLC5A1
- Official Name: solute carrier family 5 member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6523
- UniProt: P13866
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
- UniProt Summary: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3245
- Expression level (log2 read counts): -0.8
SLC5A1 Expression in NALM6 Cells: -0.8
