SLC6A12

Entrez Summary: N/A
UniProt Summary: Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

gamma-aminobutyric acid:sodium symporter activity
neurotransmitter binding
gamma-aminobutyric acid transport
amino acid transmembrane transporter activity
amino acid transmembrane transport
amino acid transport
organic acid transmembrane transport
carboxylic acid transmembrane transport
monocarboxylic acid transport
neurotransmitter transport
anion transmembrane transport
organic acid transport
carboxylic acid transport
neuron projection
organic anion transport
anion transport
ion transmembrane transport
transmembrane transport
ion transport
integral component of plasma membrane
nitrogen compound transport