SLC9A9

Entrez Summary: This gene encodes a sodium/proton exchanger that is a member of the solute carrier 9 protein family. The encoded protein localizes the to the late recycling endosomes and may play an important role in maintaining cation homeostasis. Mutations in this gene are associated with autism susceptibility 16 and attention-deficit/hyperactivity disorder. [provided by RefSeq, Mar 2012].
UniProt Summary: May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell. {ECO:0000269|PubMed:15522866}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.92
Dynasore 7μM R08 exp436	-1.73
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.71
Senexin-A 25μM R07 exp400	2.04

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

potassium:proton antiporter activity
sodium:proton antiporter activity
sodium ion import across plasma membrane
inorganic ion import across plasma membrane
inorganic cation import across plasma membrane
regulation of intracellular pH
sodium ion transmembrane transport
regulation of cellular pH
import across plasma membrane
regulation of pH
cellular monovalent inorganic cation homeostasis
recycling endosome
late endosome membrane
monovalent inorganic cation homeostasis
proton transmembrane transport
sodium ion transport
potassium ion transmembrane transport
potassium ion transport
anion transmembrane transport
monovalent inorganic cation transport
inorganic cation transmembrane transport
anion transport
cation transmembrane transport
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
import into cell
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cation transport
cellular homeostasis
ion transmembrane transport
chemical homeostasis
transmembrane transport
ion transport
homeostatic process