SMAD5

Gene Information
  • Official Symbol: SMAD5
  • Official Name: SMAD family member 5
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 4090
  • UniProt: Q99717
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
  • UniProt Summary: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 15708
  • Expression level (log2 read counts): 6.23

Expression Distribution

  • Last modified: 2026/01/07 22:37
  • by 127.0.0.1