SMAP1

Entrez Summary: N/A
UniProt Summary: GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of clathrin-dependent endocytosis
positive regulation of erythrocyte differentiation
clathrin binding
regulation of erythrocyte differentiation
positive regulation of myeloid cell differentiation
regulation of receptor-mediated endocytosis
positive regulation of hemopoiesis
regulation of endocytosis
regulation of myeloid cell differentiation
GTPase activator activity
positive regulation of GTPase activity
regulation of hemopoiesis
regulation of GTPase activity
regulation of vesicle-mediated transport
positive regulation of hydrolase activity
positive regulation of cell differentiation
positive regulation of immune system process
regulation of hydrolase activity
positive regulation of developmental process
positive regulation of catalytic activity
regulation of immune system process
positive regulation of multicellular organismal process
positive regulation of molecular function
regulation of cell differentiation
regulation of transport