SMEK2

Entrez Summary: N/A
UniProt Summary: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein phosphatase 4 complex
positive regulation of gluconeogenesis
positive regulation of glucose metabolic process
regulation of gluconeogenesis
positive regulation of cellular carbohydrate metabolic process
positive regulation of carbohydrate metabolic process
regulation of carbohydrate biosynthetic process
regulation of glucose metabolic process
positive regulation of small molecule metabolic process
regulation of cellular carbohydrate metabolic process
regulation of carbohydrate metabolic process
protein dephosphorylation
dephosphorylation
regulation of lipid metabolic process
nuclear speck
regulation of small molecule metabolic process
centrosome
positive regulation of cellular biosynthetic process
positive regulation of biosynthetic process