SMO

Gene Information

Official Symbol: SMO
Official Name: smoothened, frizzled class receptor
Aliases and Previous Symbols: N/A
Entrez ID: 6608
UniProt: Q99835
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010].
UniProt Summary: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:P56726, ECO:0000269|PubMed:19592253}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7958
Expression level (log2 read counts): -1.24

Expression Distribution

Screen	Score
BAY-598 4μM R05 exp220	-1.98
Cabazitaxel 0.001μM R05 exp223	-1.96
OICR-9429 10μM R03 exp142	1.72
Apcin 25μM plus proTAME 2μM R04 exp177	1.8

Fz
Frizzled

detection of cell density
detection of cell density by contact stimulus
mesenchymal to epithelial transition involved in renal vesicle formation
mesenchymal to epithelial transition involved in metanephric renal vesicle formation
detection of cell density by contact stimulus involved in contact inhibition
ventral midline determination
positive regulation of hh target transcription factor activity
ventral midline development
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
negative regulation of hair follicle development
smoothened signaling pathway involved in ventral spinal cord patterning
signal transduction downstream of smoothened
pancreas morphogenesis
metanephric renal vesicle formation
negative regulation of hair cycle
cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
epithelial-mesenchymal cell signaling
renal vesicle formation
determination of left/right asymmetry in lateral mesoderm
mesenchymal to epithelial transition involved in metanephros morphogenesis
positive regulation of cerebellar granule cell precursor proliferation
patched binding
contact inhibition
metanephric renal vesicle morphogenesis
regulation of cerebellar granule cell precursor proliferation
forebrain morphogenesis
lateral mesoderm development
renal vesicle morphogenesis
commissural neuron axon guidance
myoblast migration
midgut development
left/right axis specification
thalamus development
renal vesicle development
type B pancreatic cell development
mesenchymal to epithelial transition
atrial septum morphogenesis
dentate gyrus development
mammary gland epithelial cell differentiation
dorsal/ventral neural tube patterning