SNRPC

Entrez Summary: N/A
UniProt Summary: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. {ECO:0000255|HAMAP- Rule:MF_03153, ECO:0000269|PubMed:1826349, ECO:0000269|PubMed:2136774, ECO:0000269|PubMed:8798632}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 688/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	26/28
bone	23/26
breast	31/33
central nervous system	51/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	14/16
kidney	19/21
liver	18/20
lung	71/75
lymphocyte	14/16
ovary	26/26
pancreas	21/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	23/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	26/29
uterus	5/5

Expression Distribution

pre-mRNA 5-splice site binding
commitment complex
U1 snRNP binding
mRNA 5-splice site recognition
U1 snRNA binding
U2-type prespliceosome
U1 snRNP
mRNA splice site selection
mRNA cis splicing, via spliceosome
spliceosomal snRNP assembly
single-stranded RNA binding
Cajal body
spliceosomal complex assembly
mRNA binding
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
zinc ion binding
cellular protein-containing complex assembly
RNA processing
protein homodimerization activity
RNA binding
protein-containing complex assembly
RNA metabolic process
protein-containing complex subunit organization
gene expression