SNX17

Entrez Summary: N/A
UniProt Summary: Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sterol catabolic process
cholesterol catabolic process
low-density lipoprotein particle receptor binding
steroid catabolic process
retrograde transport, endosome to plasma membrane
endocytic recycling
coronary vasculature development
aorta development
alcohol catabolic process
organic hydroxy compound catabolic process
artery development
phosphatidylinositol binding
vesicle-mediated transport to the plasma membrane
cardiac septum development
cholesterol metabolic process
secondary alcohol metabolic process
sterol metabolic process
cytoplasmic vesicle membrane
cardiac chamber development
protein C-terminus binding
regulation of endocytosis
endosome membrane
endosomal transport
receptor-mediated endocytosis
cytoplasmic vesicle
early endosome
steroid metabolic process
endosome
lipid catabolic process
alcohol metabolic process
signaling receptor binding
small molecule catabolic process
organic hydroxy compound metabolic process
organic cyclic compound catabolic process
blood vessel development
vasculature development
cardiovascular system development
heart development
regulation of vesicle-mediated transport
endocytosis