SOAT2

Entrez Summary: N/A
UniProt Summary: Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CHIR-124 0.04μM R06 exp272	1.75
2-Methoxyestradiol 0.55μM R07 exp310	1.87

cholesterol O-acyltransferase activity
steroid esterification
sterol esterification
cholesterol esterification
foam cell differentiation
macrophage derived foam cell differentiation
intestinal cholesterol absorption
very-low-density lipoprotein particle assembly
intestinal lipid absorption
lipid digestion
fatty-acyl-CoA binding
cholesterol efflux
transferase activity, transferring acyl groups
low-density lipoprotein particle clearance
plasma lipoprotein particle assembly
protein-lipid complex assembly
intestinal absorption
plasma lipoprotein particle clearance
plasma lipoprotein particle organization
protein-lipid complex subunit organization
cholesterol binding
brush border
cholesterol transport
sterol transport
regulation of plasma lipoprotein particle levels
digestive system process
cholesterol homeostasis
sterol homeostasis
digestion
cholesterol metabolic process
secondary alcohol metabolic process
lipid homeostasis
sterol metabolic process
organic hydroxy compound transport
lipid modification
steroid metabolic process
lipid transport
alcohol metabolic process
lipid localization
extracellular structure organization