SOCS3

Gene Information

Official Symbol: SOCS3
Official Name: suppressor of cytokine signaling 3
Aliases and Previous Symbols: N/A
Entrez ID: 9021
UniProt: O14543
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008].
UniProt Summary: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). {ECO:0000250, ECO:0000269|PubMed:15601820}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 32/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	3/26
breast	1/33
central nervous system	5/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	3/21
liver	1/20
lung	1/75
lymphocyte	0/16
ovary	3/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	3/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	0/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 3266
Expression level (log2 read counts): -3.8

Expression Distribution

Screen	Score
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.76
BRD2 inhibitor II 20μM R07 exp341	2.4

SH2
SOCS box

spongiotrophoblast differentiation
spongiotrophoblast layer development
negative regulation of tyrosine phosphorylation of STAT protein
branching involved in labyrinthine layer morphogenesis
trophoblast giant cell differentiation
1-phosphatidylinositol-3-kinase regulator activity
interleukin-6-mediated signaling pathway
phosphatidylinositol 3-kinase complex
negative regulation of receptor signaling pathway via JAK-STAT
negative regulation of receptor signaling pathway via STAT
labyrinthine layer morphogenesis
regulation of response to interferon-gamma
regulation of interferon-gamma-mediated signaling pathway
cell differentiation involved in embryonic placenta development
embryonic placenta morphogenesis
protein kinase inhibitor activity
placenta blood vessel development
cellular response to interleukin-6
negative regulation of insulin receptor signaling pathway
response to interleukin-6
negative regulation of cellular response to insulin stimulus
receptor signaling pathway via JAK-STAT
receptor signaling pathway via STAT
phosphotyrosine residue binding
labyrinthine layer development
phosphatidylinositol phosphorylation
negative regulation of peptidyl-tyrosine phosphorylation
regulation of phosphatidylinositol 3-kinase activity
regulation of lipid kinase activity
regulation of insulin receptor signaling pathway
lipid phosphorylation
positive regulation of tyrosine phosphorylation of STAT protein
regulation of cellular response to insulin stimulus
regulation of tyrosine phosphorylation of STAT protein
positive regulation of receptor signaling pathway via JAK-STAT
regulation of phospholipid metabolic process
embryonic placenta development
positive regulation of receptor signaling pathway via STAT
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor