SOX11
Gene Information
- Official Symbol: SOX11
- Official Name: SRY-box transcription factor 11
- Aliases and Previous Symbols: N/A
- Entrez ID: 6664
- UniProt: P35716
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq, Jul 2008].
- UniProt Summary: Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development. {ECO:0000269|PubMed:24886874}.
Pfam Domains GO Terms
Pfam Domains
| HMG box |
GO Terms
| closure of optic fissure |
| regulation of lens epithelial cell proliferation |
| positive regulation of lens epithelial cell proliferation |
| positive regulation of hippo signaling |
| soft palate development |
| hard palate development |
| noradrenergic neuron differentiation |
| optic cup morphogenesis involved in camera-type eye development |
| cornea development in camera-type eye |
| cardiac ventricle formation |
| limb bud formation |
| cardiac chamber formation |
| regulation of hippo signaling |
| embryonic camera-type eye formation |
| eyelid development in camera-type eye |
| negative regulation of glial cell proliferation |
| glial cell proliferation |
| embryonic digestive tract morphogenesis |
| sympathetic nervous system development |
| negative regulation of transcription regulatory region DNA binding |
| lens morphogenesis in camera-type eye |
| secondary palate development |
| enhancer sequence-specific DNA binding |
| nuclear transcription factor complex |
| embryonic camera-type eye morphogenesis |
| regulation of glial cell proliferation |
| positive regulation of BMP signaling pathway |
| embryonic eye morphogenesis |
| embryonic digestive tract development |
| embryonic camera-type eye development |
| positive regulation of stem cell proliferation |
| negative regulation of gliogenesis |
| ventricular septum morphogenesis |
| oligodendrocyte development |
| lung morphogenesis |
| neuroepithelial cell differentiation |
| autonomic nervous system development |
| digestive tract morphogenesis |
| morphogenesis of an epithelial sheet |
| skeletal muscle cell differentiation |
| regulation of transcription regulatory region DNA binding |
| negative regulation of DNA binding |
| positive regulation of osteoblast differentiation |
| regulation of stem cell proliferation |
| oligodendrocyte differentiation |
| ventricular septum development |
| signal transduction involved in cell cycle checkpoint |
| outflow tract morphogenesis |
| cardiac septum morphogenesis |
| cardiac ventricle morphogenesis |
| negative regulation of mononuclear cell proliferation |
| negative regulation of lymphocyte proliferation |
| transcription regulatory region sequence-specific DNA binding |
| lens development in camera-type eye |
| neural crest cell development |
| negative regulation of leukocyte proliferation |
| somite development |
| mesenchymal cell development |
| stem cell development |
| positive regulation of ossification |
| regulation of BMP signaling pathway |
| neural crest cell differentiation |
| roof of mouth development |
| embryonic skeletal system morphogenesis |
| columnar/cuboidal epithelial cell differentiation |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| neural tube formation |
| spinal cord development |
| glial cell development |
| cardiac septum development |
| regulation of osteoblast differentiation |
| camera-type eye morphogenesis |
| regulation of transforming growth factor beta receptor signaling pathway |
| regulation of cellular response to transforming growth factor beta stimulus |
| regulation of gliogenesis |
| skeletal muscle tissue development |
| embryonic epithelial tube formation |
| regulation of DNA binding |
| embryonic skeletal system development |
| cardiac chamber morphogenesis |
| cardiac ventricle development |
| positive regulation of hormone secretion |
| digestive tract development |
| epithelial tube formation |
| skeletal muscle organ development |
| digestive system development |
| morphogenesis of embryonic epithelium |
| negative regulation of lymphocyte activation |
| eye morphogenesis |
| tube formation |
| limb morphogenesis |
| appendage morphogenesis |
| mesenchymal cell differentiation |
| stem cell differentiation |
| neural tube development |
| lung development |
| negative regulation of binding |
| cardiac chamber development |
| glial cell differentiation |
| respiratory tube development |
| negative regulation of leukocyte activation |
| limb development |
| appendage development |
| positive regulation of epithelial cell proliferation |
| regulation of ossification |
| cell cycle checkpoint |
| respiratory system development |
| negative regulation of cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| gliogenesis |
| mesenchyme development |
| regulation of leukocyte proliferation |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| skeletal system morphogenesis |
| heart morphogenesis |
| sensory organ morphogenesis |
| kidney development |
| regulation of hormone secretion |
| regulation of cellular response to growth factor stimulus |
| striated muscle tissue development |
| renal system development |
| transcription coactivator activity |
| embryonic organ morphogenesis |
| negative regulation of neurogenesis |
| muscle organ development |
| muscle tissue development |
| epithelial tube morphogenesis |
| negative regulation of nervous system development |
| camera-type eye development |
| urogenital system development |
| negative regulation of cell development |
| regulation of epithelial cell proliferation |
| eye development |
| visual system development |
| positive regulation of neuron differentiation |
| sensory system development |
| regulation of binding |
| positive regulation of secretion by cell |
| morphogenesis of an epithelium |
| embryonic organ development |
| positive regulation of secretion |
| negative regulation of immune system process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| positive regulation of neurogenesis |
| muscle structure development |
| skeletal system development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| regulation of lymphocyte activation |
| heart development |
| regulation of hormone levels |
| positive regulation of nervous system development |
| positive regulation of cell development |
| sensory organ development |
| cell population proliferation |
| tissue morphogenesis |
| embryonic morphogenesis |
| negative regulation of cell cycle |
| regulation of leukocyte activation |
| chordate embryonic development |
| regulation of cell activation |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of neuron differentiation |
| DNA-binding transcription factor activity |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| negative regulation of cell differentiation |
| regulation of secretion by cell |
| regulation of secretion |
| regulation of neurogenesis |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| embryo development |
| central nervous system development |
| positive regulation of transport |
| negative regulation of cell death |
| neuron differentiation |
| positive regulation of intracellular signal transduction |
| epithelium development |
| negative regulation of molecular function |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Benzoate 10000μM R08 exp455 | -1.85 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 3/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 3/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7702
- Expression level (log2 read counts): 0.72
Expression Distribution
SOX11 Expression in NALM6 Cells: 0.72
