SOX8
Gene Information
- Official Symbol: SOX8
- Official Name: SRY-box transcription factor 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 30812
- UniProt: P57073
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the cognitive disability found in an alpha-thalassemia-related syndrome (ART-16). This protein is also highly expressed in the majority of human hepatocellular carcinomas and promotes cellular proliferation and enhanced tumor growth. [provided by RefSeq, Jul 2017].
- UniProt Summary: May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Sox N |
| HMG box |
GO Terms
| retinal rod cell differentiation |
| renal vesicle induction |
| astrocyte fate commitment |
| metanephric nephron tubule formation |
| metanephric tubule formation |
| ureter morphogenesis |
| metanephric nephron tubule morphogenesis |
| negative regulation of photoreceptor cell differentiation |
| regulation of photoreceptor cell differentiation |
| positive regulation of osteoblast proliferation |
| metanephric tubule morphogenesis |
| enteric nervous system development |
| glial cell fate commitment |
| Sertoli cell development |
| metanephric nephron tubule development |
| ureter development |
| nephron tubule formation |
| metanephric nephron epithelium development |
| positive regulation of branching involved in ureteric bud morphogenesis |
| metanephric tubule development |
| camera-type eye photoreceptor cell differentiation |
| Sertoli cell differentiation |
| metanephric nephron morphogenesis |
| positive regulation of mesonephros development |
| metanephric epithelium development |
| regulation of branching involved in ureteric bud morphogenesis |
| regulation of osteoblast proliferation |
| nuclear transcription factor complex |
| regulation of mesonephros development |
| negative regulation of myoblast differentiation |
| developmental induction |
| metanephros morphogenesis |
| metanephric nephron development |
| positive regulation of morphogenesis of an epithelium |
| RNA polymerase II core promoter sequence-specific DNA binding |
| adipose tissue development |
| positive regulation of kidney development |
| autonomic nervous system development |
| eye photoreceptor cell differentiation |
| retina morphogenesis in camera-type eye |
| skeletal muscle cell differentiation |
| astrocyte differentiation |
| regulation of myoblast differentiation |
| neural crest cell migration |
| regulation of kidney development |
| regulation of morphogenesis of a branching structure |
| neural retina development |
| photoreceptor cell differentiation |
| nephron tubule morphogenesis |
| nephron epithelium morphogenesis |
| nephron morphogenesis |
| renal tubule morphogenesis |
| oligodendrocyte differentiation |
| positive regulation of gliogenesis |
| peripheral nervous system development |
| nephron tubule development |
| neural crest cell development |
| renal tubule development |
| positive regulation of animal organ morphogenesis |
| stem cell development |
| metanephros development |
| mesenchymal cell development |
| kidney morphogenesis |
| neural crest cell differentiation |
| nephron epithelium development |
| fat cell differentiation |
| camera-type eye morphogenesis |
| regulation of gliogenesis |
| embryonic epithelial tube formation |
| skeletal muscle tissue development |
| nephron development |
| osteoblast differentiation |
| kidney epithelium development |
| epithelial tube formation |
| skeletal muscle organ development |
| male gonad development |
| development of primary male sexual characteristics |
| retina development in camera-type eye |
| morphogenesis of embryonic epithelium |
| tube formation |
| eye morphogenesis |
| male sex differentiation |
| mesenchymal cell differentiation |
| stem cell differentiation |
| cell maturation |
| morphogenesis of a branching epithelium |
| morphogenesis of a branching structure |
| glial cell differentiation |
| ameboidal-type cell migration |
| regulation of morphogenesis of an epithelium |
| epithelial cell development |
| gonad development |
| gliogenesis |
| development of primary sexual characteristics |
| mesenchyme development |
| connective tissue development |
| negative regulation of neuron differentiation |
| developmental maturation |
| cell fate commitment |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| ossification |
| sex differentiation |
| kidney development |
| renal system development |
| striated muscle tissue development |
| negative regulation of neurogenesis |
| muscle organ development |
| muscle tissue development |
| epithelial tube morphogenesis |
| negative regulation of nervous system development |
| camera-type eye development |
| urogenital system development |
| transcription factor binding |
| negative regulation of cell development |
| eye development |
| visual system development |
| sensory system development |
| in utero embryonic development |
| reproductive structure development |
| reproductive system development |
| morphogenesis of an epithelium |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| positive regulation of neurogenesis |
| muscle structure development |
| protein heterodimerization activity |
| regulation of hormone levels |
| positive regulation of nervous system development |
| positive regulation of cell development |
| spermatogenesis |
| sensory organ development |
| male gamete generation |
| tissue morphogenesis |
| embryonic morphogenesis |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of neuron differentiation |
| developmental process involved in reproduction |
| epithelial cell differentiation |
| gamete generation |
| negative regulation of cell differentiation |
| regulation of neurogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| tube development |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| cell migration |
| positive regulation of cell differentiation |
| embryo development |
| central nervous system development |
| negative regulation of cell death |
| multi-organism reproductive process |
| neuron differentiation |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| epithelium development |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| locomotion |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of cell death |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Trametinib 10μM R02 exp83 | -1.77 |
| 42°C R08 exp539 | 1.83 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ZBP1 | 0.416 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10425
- Expression level (log2 read counts): -3.13
Expression Distribution
SOX8 Expression in NALM6 Cells: -3.13
