SPEF1

Entrez Summary: N/A
UniProt Summary: Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule- associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity). {ECO:0000250|UniProtKB:Q0IH24, ECO:0000250|UniProtKB:Q99JL1}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CAMSAP CH
DUF1042

negative regulation of microtubule depolymerization
regulation of microtubule depolymerization
negative regulation of microtubule polymerization or depolymerization
negative regulation of protein depolymerization
negative regulation of protein complex disassembly
regulation of microtubule polymerization or depolymerization
regulation of protein depolymerization
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
motile cilium
axoneme
regulation of protein complex disassembly
negative regulation of supramolecular fiber organization
negative regulation of cytoskeleton organization
regulation of microtubule cytoskeleton organization
regulation of microtubule-based process
microtubule binding
regulation of supramolecular fiber organization
negative regulation of organelle organization
cellular component
regulation of cytoskeleton organization
negative regulation of cellular component organization
molecular function
cell migration
localization of cell
cell motility
regulation of organelle organization
locomotion
movement of cell or subcellular component