SPRED1

Gene Information

Official Symbol: SPRED1
Official Name: sprouty related EVH1 domain containing 1
Aliases and Previous Symbols: N/A
Entrez ID: 161742
UniProt: Q7Z699
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008].
UniProt Summary: Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Q15 2.7μM R02 exp79	-1.71
Thimerosal 0.85μM R08 exp529	1.72
Nifurtimox 1μM R03 exp141	1.73
BI-2536 0.001μM R01 exp41	1.81
Ibrutinib 10μM R08 exp442	1.81
35°C R06 exp302	1.92
A-196 10μM R03 exp114	1.99
QNZ 0.01μM R08 exp439	2.07

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18767
Expression level (log2 read counts): 5.43

Expression Distribution

WH1
Sprouty

vasculogenesis involved in coronary vascular morphogenesis
stem cell factor receptor binding
protein serine/threonine kinase inhibitor activity
positive regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of cell migration involved in sprouting angiogenesis
coronary vasculature morphogenesis
negative regulation of peptidyl-threonine phosphorylation
positive regulation of signal transduction by p53 class mediator
negative regulation of sprouting angiogenesis
inactivation of MAPK activity
negative regulation of blood vessel endothelial cell migration
regulation of DNA damage response, signal transduction by p53 class mediator
regulation of cell migration involved in sprouting angiogenesis
regulation of protein deacetylation
regulation of peptidyl-threonine phosphorylation
coronary vasculature development
negative regulation of endothelial cell migration
phosphatase binding
negative regulation of ERK1 and ERK2 cascade
negative regulation of epithelial cell migration
vasculogenesis
regulation of sprouting angiogenesis
caveola
negative regulation of MAP kinase activity
fibroblast growth factor receptor signaling pathway
regulation of blood vessel endothelial cell migration
positive regulation of response to DNA damage stimulus
negative regulation of angiogenesis
negative regulation of phosphatase activity
negative regulation of blood vessel morphogenesis
cellular response to fibroblast growth factor stimulus
negative regulation of dephosphorylation
negative regulation of vasculature development
response to fibroblast growth factor
negative regulation of protein serine/threonine kinase activity
regulation of endothelial cell migration
negative regulation of MAPK cascade
regulation of phosphatase activity
regulation of signal transduction by p53 class mediator
regulation of dephosphorylation