SPRED2

Gene Information

Official Symbol: SPRED2
Official Name: sprouty related EVH1 domain containing 2
Aliases and Previous Symbols: N/A
Entrez ID: 200734
UniProt: Q7Z698
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. {ECO:0000269|PubMed:15683364}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-D1870 3.15μM R02 exp66	1.73
LLY-284 2.6μM R06 exp291	1.78
Dynasore 10μM R04 exp180	1.89
GSK626616 14μM R08 exp485	1.94
Wortmannin 5μM R00 exp38	2.24

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7801
Expression level (log2 read counts): 5.05

Expression Distribution

Gene	Correlation
NF1	0.517
DUSP6	0.453
ZDHHC17	0.437
RFWD2	0.425
LZTR1	0.422

Sprouty
WH1

stem cell factor receptor binding
protein serine/threonine kinase inhibitor activity
positive regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of peptidyl-threonine phosphorylation
positive regulation of signal transduction by p53 class mediator
inactivation of MAPK activity
regulation of DNA damage response, signal transduction by p53 class mediator
transport vesicle membrane
regulation of protein deacetylation
regulation of peptidyl-threonine phosphorylation
negative regulation of MAP kinase activity
fibroblast growth factor receptor signaling pathway
positive regulation of response to DNA damage stimulus
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
negative regulation of protein serine/threonine kinase activity
negative regulation of MAPK cascade
regulation of signal transduction by p53 class mediator
regulation of response to DNA damage stimulus
negative regulation of protein kinase activity
negative regulation of kinase activity
negative regulation of transferase activity
regulation of MAP kinase activity
negative regulation of protein phosphorylation
negative regulation of phosphorylation
protein kinase binding
cellular response to growth factor stimulus
negative regulation of intracellular signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of protein serine/threonine kinase activity
response to growth factor
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
enzyme linked receptor protein signaling pathway
regulation of cellular response to stress
regulation of MAPK cascade
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity