SRD5A2

Entrez Summary: This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008].
UniProt Summary: Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. {ECO:0000269|PubMed:10898110}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

sterol 5-alpha reductase activity
testosterone dehydrogenase [NAD(P)] activity
3-oxo-5-alpha-steroid 4-dehydrogenase activity
cholestenone 5-alpha-reductase activity
testosterone biosynthetic process
androgen biosynthetic process
male genitalia development
androgen metabolic process
ketone biosynthetic process
steroid hormone biosynthetic process
genitalia development
hormone biosynthetic process
cellular ketone metabolic process
oxidoreductase activity
cellular hormone metabolic process
steroid biosynthetic process
male gonad development
development of primary male sexual characteristics
male sex differentiation
organic hydroxy compound biosynthetic process
hormone metabolic process
gonad development
development of primary sexual characteristics
steroid metabolic process
sex differentiation
reproductive structure development
reproductive system development
organic hydroxy compound metabolic process
regulation of hormone levels
lipid biosynthetic process
small molecule biosynthetic process
developmental process involved in reproduction
endoplasmic reticulum membrane
oxidation-reduction process
cell-cell signaling
lipid metabolic process
organic cyclic compound biosynthetic process
reproductive process
reproduction
small molecule metabolic process