SRPR

Entrez Summary: N/A
UniProt Summary: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 38/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	0/28
blood	1/28
bone	3/26
breast	4/33
central nervous system	1/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	2/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	1/29
uterus	0/5

Expression Distribution

signal recognition particle binding
signal recognition particle receptor complex
IRE1-mediated unfolded protein response
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
endoplasmic reticulum unfolded protein response
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
cellular response to unfolded protein
protein localization to endoplasmic reticulum
cellular response to topologically incorrect protein
protein targeting to membrane
response to unfolded protein
response to topologically incorrect protein
response to endoplasmic reticulum stress
establishment of protein localization to membrane
GTPase activity
protein targeting
GTP binding
establishment of protein localization to organelle
protein localization to membrane
protein localization to organelle
endoplasmic reticulum membrane
intracellular protein transport
RNA binding
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
cellular response to stress
establishment of localization in cell
nitrogen compound transport
membrane