SS18L1

Gene Information

Official Symbol: SS18L1
Official Name: SS18L1 subunit of BAF chromatin remodeling complex
Aliases and Previous Symbols: N/A
Entrez ID: 26039
UniProt: O75177
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a calcium-responsive transactivator which is an essential subunit of a neuron-specific chromatin-remodeling complex. The structure of this gene is similar to that of the SS18 gene. Mutations in this gene are involved in amyotrophic lateral sclerosis (ALS). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5828
Expression level (log2 read counts): 5.45

Expression Distribution

Screen	Score
Etoposide 0.1μM R05 exp198	-2.03
BML-284 0.09μM R08 exp460	1.88

condensed nuclear chromosome, centromeric region
nBAF complex
positive regulation of dendrite morphogenesis
positive regulation of dendrite development
kinetochore
condensed chromosome kinetochore
regulation of dendrite morphogenesis
dendrite development
regulation of dendrite development
positive regulation of cell morphogenesis involved in differentiation
positive regulation of neuron projection development
nuclear body
transcription coactivator activity
regulation of cell morphogenesis involved in differentiation
positive regulation of neuron differentiation
positive regulation of cell projection organization
positive regulation of neurogenesis
regulation of cell morphogenesis
regulation of neuron projection development
positive regulation of nervous system development
positive regulation of cell development
regulation of neuron differentiation
neuron projection development
regulation of plasma membrane bounded cell projection organization
chromatin organization
regulation of cell projection organization
neuron development
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
neuron differentiation
regulation of anatomical structure morphogenesis
chromosome organization
plasma membrane bounded cell projection organization
cell projection organization
positive regulation of cellular component organization
positive regulation of transcription by RNA polymerase II
positive regulation of developmental process
generation of neurons