ST6GALNAC4

Entrez Summary: N/A
UniProt Summary: Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MLN-4924 2μM R00 exp22	-1.79
Citral 75μM R06 exp275	-1.77
Epigallocatechin gallate 20μM R05 exp230	1.75
Bleomycin 5μM R08 exp459	1.76
Nifurtimox 1μM R03 exp141	1.82
Ribavirin 10μM R01 exp52	1.82

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity
sialyltransferase activity
sialylation
O-glycan processing
glycolipid metabolic process
liposaccharide metabolic process
protein O-linked glycosylation
membrane lipid metabolic process
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate derivative biosynthetic process
Golgi membrane
cellular lipid metabolic process
carbohydrate derivative metabolic process
lipid metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process