ST8SIA3

Entrez Summary: N/A
UniProt Summary: Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid. {ECO:0000269|PubMed:10766765, ECO:0000269|PubMed:26192331, ECO:0000269|PubMed:9826427}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein sialylation
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
ganglioside biosynthetic process
sialic acid binding
N-glycan processing
sialyltransferase activity
ganglioside metabolic process
sialylation
glycosphingolipid biosynthetic process
ceramide biosynthetic process
oligosaccharide metabolic process
glycosphingolipid metabolic process
glycolipid biosynthetic process
ceramide metabolic process
sphingolipid biosynthetic process
glycolipid metabolic process
liposaccharide metabolic process
membrane lipid biosynthetic process
sphingolipid metabolic process
membrane lipid metabolic process
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate metabolic process
amide biosynthetic process
lipid biosynthetic process
Golgi membrane
carbohydrate derivative biosynthetic process
cellular amide metabolic process
cellular lipid metabolic process
carbohydrate derivative metabolic process
identical protein binding
lipid metabolic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process