STATH

Entrez Summary: N/A
UniProt Summary: Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

extracellular matrix constituent, lubricant activity
hydroxyapatite binding
saliva secretion
structural constituent of tooth enamel
negative regulation of bone mineralization
secretion by tissue
negative regulation of biomineral tissue development
negative regulation of biomineralization
digestive system process
body fluid secretion
negative regulation of ossification
regulation of bone mineralization
regulation of biomineral tissue development
regulation of biomineralization
biomineral tissue development
biomineralization
digestion
regulation of ossification
ossification
defense response to bacterium
regulation of body fluid levels
response to bacterium
negative regulation of developmental process
defense response to other organism
secretion
negative regulation of multicellular organismal process
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
tissue development
extracellular region
system process