STX12

Entrez Summary: N/A
UniProt Summary: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:G3V7P1}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SNARE
Syntaxin

postsynaptic recycling endosome
BLOC-1 complex
cholesterol efflux
phagophore assembly site
SNAP receptor activity
integral component of synaptic vesicle membrane
SNARE complex
cholesterol transport
phagocytic vesicle
autophagosome assembly
vesicle docking
SNARE binding
autophagosome organization
sterol transport
vesicle fusion
endomembrane system
organelle membrane fusion
recycling endosome membrane
organelle fusion
synaptic vesicle
vacuole organization
membrane fusion
organic hydroxy compound transport
vesicle
early endosome membrane
macroautophagy
organelle localization by membrane tethering
protein stabilization
membrane docking
membrane raft
autophagy
process utilizing autophagic mechanism
regulation of protein stability
lipid transport
vesicle organization
lipid localization
organelle localization
Golgi membrane
organelle assembly
membrane organization