STX2

Entrez Summary: N/A
UniProt Summary: Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Syntaxin
SNARE

cornified envelope assembly
presynaptic active zone membrane
synaptic vesicle fusion to presynaptic active zone membrane
vesicle fusion to plasma membrane
response to hydroperoxide
ectoderm development
acrosome reaction
SNAP receptor activity
membrane assembly
membrane biogenesis
SNARE complex
calcium-dependent protein binding
vesicle docking
synaptic vesicle exocytosis
SNARE binding
exocytic process
vesicle fusion
presynaptic membrane
endomembrane system
organelle membrane fusion
plasma membrane organization
organelle fusion
neurotransmitter secretion
signal release from synapse
synaptic vesicle cycle
synaptic vesicle
vesicle-mediated transport in synapse
membrane fusion
single fertilization
protein dimerization activity
signal release
organelle localization by membrane tethering
fertilization
membrane docking
neurotransmitter transport
lamellipodium
basolateral plasma membrane
vesicle organization
regulation of neurotransmitter levels
response to oxidative stress