SULT2A1

Entrez Summary: This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010].
UniProt Summary: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rifampicin 30μM R08 exp430	-1.72
Hydroxyurea 15μM R06 exp289	-1.71

bile-salt sulfotransferase activity
bile acid catabolic process
steroid sulfotransferase activity
ethanol catabolic process
primary alcohol catabolic process
sulfation
ethanol metabolic process
3-phosphoadenosine 5-phosphosulfate metabolic process
purine ribonucleoside bisphosphate metabolic process
sulfotransferase activity
bile acid metabolic process
antibiotic catabolic process
alcohol catabolic process
organic hydroxy compound catabolic process
primary alcohol metabolic process
antibiotic metabolic process
monocarboxylic acid catabolic process
ribonucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
drug catabolic process
steroid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
purine ribonucleotide metabolic process
alcohol metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process
regulation of lipid metabolic process
small molecule catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organic hydroxy compound metabolic process
drug metabolic process
monocarboxylic acid metabolic process
nucleobase-containing small molecule metabolic process