SYNPO2

Gene Information

Official Symbol: SYNPO2
Official Name: synaptopodin 2
Aliases and Previous Symbols: N/A
Entrez ID: 171024
UniProt: Q9UMS6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client- processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}. Isoform 2: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}. Isoform 4: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7372
Expression level (log2 read counts): 2.84

Expression Distribution

Screen	Score
Menadione 5μM R06 exp292	-1.8
Vinorelbine 0.001μM R05 exp249	-1.73
Salinomycin 3.5μM R08 exp521	1.72

vesicle tethering complex
chaperone-mediated autophagy
filamin binding
alpha-actinin binding
muscle alpha-actinin binding
14-3-3 protein binding
positive regulation of actin filament bundle assembly
autophagosome assembly
autophagosome organization
stress fiber
protein binding, bridging
regulation of actin filament bundle assembly
vacuole organization
Z disc
macroautophagy
positive regulation of supramolecular fiber organization
actin cytoskeleton
positive regulation of cytoskeleton organization
regulation of actin filament organization
process utilizing autophagic mechanism
autophagy
actin binding
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
regulation of actin filament-based process
focal adhesion
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
positive regulation of organelle organization
protein catabolic process
intracellular membrane-bounded organelle
organelle assembly
regulation of cellular component biogenesis
macromolecule catabolic process
organonitrogen compound catabolic process
positive regulation of cellular component organization
regulation of organelle organization
organic substance catabolic process
cellular catabolic process