TANK

Gene Information

Official Symbol: TANK
Official Name: TRAF family member associated NFKB activator
Aliases and Previous Symbols: N/A
Entrez ID: 10010
UniProt: Q92844
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12413
Expression level (log2 read counts): 3.8

Expression Distribution

positive regulation of ubiquitin-specific protease activity
deubiquitinase activator activity
regulation of ubiquitin-specific protease activity
positive regulation of protein deubiquitination
regulation of protein deubiquitination
TRIF-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
negative regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to ionizing radiation
I-kappaB kinase/NF-kappaB signaling
toll-like receptor signaling pathway
thiol-dependent ubiquitin-specific protease activity
pattern recognition receptor signaling pathway
positive regulation of protein modification by small protein conjugation or removal
response to ionizing radiation
cellular response to radiation
cellular response to interleukin-1
positive regulation of peptidase activity
response to interleukin-1
regulation of protein modification by small protein conjugation or removal
innate immune response-activating signal transduction
regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to tumor necrosis factor
activation of innate immune response
response to tumor necrosis factor
ubiquitin protein ligase binding
cellular response to environmental stimulus
cellular response to abiotic stimulus
positive regulation of innate immune response
positive regulation of proteolysis
positive regulation of response to biotic stimulus
response to radiation
regulation of peptidase activity
regulation of innate immune response
positive regulation of defense response
negative regulation of intracellular signal transduction
positive regulation of multi-organism process
regulation of response to biotic stimulus
immune response-activating signal transduction
protein-containing complex