TCEB2

Entrez Summary: N/A
UniProt Summary: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). {ECO:0000250|UniProtKB:P62869, ECO:0000269|PubMed:7638163}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 679/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	25/28
blood	27/28
bone	24/25
breast	32/33
central nervous system	53/56
cervix	4/4
colorectal	13/17
esophagus	13/13
fibroblast	1/1
gastric	14/15
kidney	13/21
liver	20/20
lung	66/75
lymphocyte	13/14
ovary	24/26
pancreas	23/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

Screen	Score
35°C R06 exp302	-1.75
2-Methoxyestradiol 0.2μM R01 exp40	1.76

VCB complex
Cul5-RING ubiquitin ligase complex
elongin complex
Cul2-RING ubiquitin ligase complex
transcription elongation from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter in response to hypoxia
DNA-templated transcription, elongation
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
cellular response to hypoxia
cellular response to decreased oxygen levels
cellular response to oxygen levels
ubiquitin protein ligase binding
response to hypoxia
response to decreased oxygen levels
post-translational protein modification
response to oxygen levels
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
protein ubiquitination
protein modification by small protein conjugation
protein modification by small protein conjugation or removal
nucleobase-containing compound biosynthetic process
response to abiotic stimulus
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression