TDRD7

Entrez Summary: The protein encoded by this gene belongs to the Tudor family of proteins. This protein contains conserved Tudor domains and LOTUS domains. It is a component of RNA granules, which function in RNA processing. Mutations in this gene have been associated with cataract formation in mouse and human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
GSK-J5 1.5μM R08 exp484	1.86
BI-2536 0.02μM R03 exp96	2.53

TUDOR
OST LOTUS

ribonucleoprotein granule
chromatoid body
lens morphogenesis in camera-type eye
lens fiber cell differentiation
lens development in camera-type eye
protein N-terminus binding
camera-type eye morphogenesis
eye morphogenesis
mRNA binding
sensory organ morphogenesis
camera-type eye development
eye development
visual system development
sensory system development
mitochondrial matrix
posttranscriptional regulation of gene expression
spermatogenesis
sensory organ development
male gamete generation
epithelial cell differentiation
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
animal organ morphogenesis
multi-organism reproductive process
epithelium development
reproductive process
reproduction
tissue development