TEKT2

Entrez Summary: N/A
UniProt Summary: Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. {ECO:0000250|UniProtKB:Q922G7}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Palbociclib 1μM R07 exp382	-1.9
UM0011500 10μM R05 exp246	1.82

inner dynein arm assembly
cilium movement involved in cell motility
axonemal dynein complex assembly
cilium movement
axoneme assembly
flagellated sperm motility
sperm motility
microtubule bundle formation
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
motile cilium
microtubule cytoskeleton
microtubule organizing center
microtubule-based movement
microtubule
cilium assembly
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
microtubule cytoskeleton organization
microtubule-based process
organelle assembly
cellular protein-containing complex assembly
localization of cell
cell motility
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization
locomotion
reproductive process
reproduction
movement of cell or subcellular component
protein-containing complex assembly
protein-containing complex subunit organization