TENM1

Gene Information

Official Symbol: TENM1
Official Name: teneurin transmembrane protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 10178
UniProt: Q9UKZ4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
UniProt Summary: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). {ECO:0000250}. Ten-1 intracellular domain: Induces gene transcription activation. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8719
Expression level (log2 read counts): 1.27

Expression Distribution

Screen	Score
Atovaquone 15μM R08 exp451	-1.83
Apcin 25μM plus proTAME 2μM R04 exp177	-1.71

regulation of transcription by RNA polymerase III
positive regulation of filopodium assembly
regulation of filopodium assembly
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
cell adhesion molecule binding
positive regulation of actin filament polymerization
positive regulation of plasma membrane bounded cell projection assembly
positive regulation of peptidyl-serine phosphorylation
neuropeptide signaling pathway
nuclear matrix
positive regulation of protein polymerization
regulation of peptidyl-serine phosphorylation
positive regulation of intracellular protein transport
regulation of actin filament polymerization
heparin binding
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
positive regulation of intracellular transport
positive regulation of cytoskeleton organization
regulation of protein polymerization
regulation of intracellular protein transport
positive regulation of protein complex assembly
cell-cell adhesion via plasma-membrane adhesion molecules
regulation of actin filament organization
positive regulation of MAP kinase activity
neuron projection
positive regulation of cellular protein localization
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
regulation of actin cytoskeleton organization
regulation of intracellular transport
regulation of supramolecular fiber organization
cytoskeleton
regulation of cellular component size
positive regulation of cell projection organization
regulation of actin filament-based process
nuclear speck