TEX101

Entrez Summary: N/A
UniProt Summary: Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q924B5, ECO:0000250|UniProtKB:Q9JMI7}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
PU-H71 1μM R08 exp515	-1.81
Nifuroxazide 1μM R01 exp51	-1.72

regulation of flagellated sperm motility
regulation of cilium-dependent cell motility
anchored component of plasma membrane
binding of sperm to zona pellucida
sperm-egg recognition
cell-cell recognition
sperm motility
flagellated sperm motility
acrosomal vesicle
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
single fertilization
regulation of reproductive process
fertilization
membrane raft
cell recognition
sexual reproduction
regulation of cell motility
regulation of locomotion
multi-organism reproductive process
regulation of cellular component movement
cell motility
localization of cell
locomotion
reproductive process
reproduction
movement of cell or subcellular component
extracellular region