TFF1

Entrez Summary: N/A
UniProt Summary: Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. {ECO:0000269|PubMed:16308573}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Latrunculin-B 10μM R07 exp374	-2.01
Epigallocatechin gallate 20μM R05 exp230	1.89
Aminopterin 0.005μM R07 exp335	2.45

maintenance of gastrointestinal epithelium
epithelial structure maintenance
response to immobilization stress
response to iron ion
digestive system process
digestion
growth factor activity
tissue homeostasis
multicellular organismal homeostasis
anatomical structure homeostasis
response to metal ion
response to peptide hormone
response to peptide
carbohydrate metabolic process
response to inorganic substance
negative regulation of cell population proliferation
response to hormone
response to organonitrogen compound
response to nitrogen compound
response to endogenous stimulus
response to oxygen-containing compound
extracellular space
regulation of cell population proliferation
homeostatic process
extracellular region
system process