THBS1
Gene Information
- Official Symbol: THBS1
- Official Name: thrombospondin 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 7057
- UniProt: P07996
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). {ECO:0000250, ECO:0000269|PubMed:11134179, ECO:0000269|PubMed:15014436}.
Pfam Domains GO Terms
Pfam Domains
| VWC |
| TSP 1 |
| EGF 3 |
| EGF CA |
| TSP C |
GO Terms
| collagen V binding |
| negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| negative regulation of nitric oxide mediated signal transduction |
| negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| negative regulation of long-chain fatty acid import across plasma membrane |
| negative regulation of long-chain fatty acid import into cell |
| regulation of long-chain fatty acid import across plasma membrane |
| negative regulation of dendritic cell antigen processing and presentation |
| negative regulation of endothelial cell chemotaxis |
| regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| fibrinogen binding |
| regulation of long-chain fatty acid import into cell |
| negative regulation of plasminogen activation |
| negative regulation of cGMP-mediated signaling |
| positive regulation of transforming growth factor beta1 production |
| negative regulation of fatty acid transport |
| fibrinogen complex |
| negative regulation of antigen processing and presentation |
| regulation of nitric oxide mediated signal transduction |
| negative regulation of fibrinolysis |
| chronic inflammatory response |
| regulation of dendritic cell antigen processing and presentation |
| regulation of transforming growth factor beta1 production |
| positive regulation of fibroblast migration |
| engulfment of apoptotic cell |
| regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| regulation of plasminogen activation |
| regulation of cGMP-mediated signaling |
| platelet alpha granule |
| behavioral response to pain |
| regulation of fibrinolysis |
| proteoglycan binding |
| positive regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| negative regulation of anion transmembrane transport |
| negative regulation of cell migration involved in sprouting angiogenesis |
| positive regulation of macrophage chemotaxis |
| negative regulation of interleukin-12 production |
| low-density lipoprotein particle binding |
| negative regulation of fibroblast growth factor receptor signaling pathway |
| negative regulation of focal adhesion assembly |
| positive regulation of transforming growth factor beta production |
| positive regulation of endothelial cell apoptotic process |
| positive regulation of macrophage migration |
| negative regulation of organic acid transport |
| positive regulation of tumor necrosis factor biosynthetic process |
| regulation of antigen processing and presentation |
| response to magnesium ion |
| negative regulation of adherens junction organization |
| regulation of endothelial cell chemotaxis |
| transforming growth factor beta binding |
| negative regulation of cell junction assembly |
| fibroblast growth factor binding |
| positive regulation of macrophage activation |
| negative regulation of sprouting angiogenesis |
| laminin binding |
| negative regulation of lipid transport |
| positive regulation of blood coagulation |
| regulation of macrophage chemotaxis |
| positive regulation of hemostasis |
| regulation of anion transmembrane transport |
| positive regulation of coagulation |
| fibronectin binding |
| regulation of fatty acid transport |
| negative regulation of anion transport |
| positive regulation of cellular response to transforming growth factor beta stimulus |
| regulation of fibroblast growth factor receptor signaling pathway |
| positive regulation of transforming growth factor beta receptor signaling pathway |
| response to pain |
| regulation of fibroblast migration |
| regulation of tumor necrosis factor biosynthetic process |
| positive regulation of epithelial cell apoptotic process |
| negative regulation of blood vessel endothelial cell migration |
| negative regulation of protein processing |
| negative regulation of protein maturation |
| regulation of transforming growth factor beta production |
| negative regulation of endothelial cell proliferation |
| regulation of macrophage migration |
| negative regulation of cell-matrix adhesion |
| response to testosterone |
| regulation of cell migration involved in sprouting angiogenesis |
| apoptotic cell clearance |
| negative regulation of lipid localization |
| regulation of granulocyte chemotaxis |
| sarcoplasmic reticulum |
| response to progesterone |
| regulation of mononuclear cell migration |
| positive regulation of extrinsic apoptotic signaling pathway |
| negative regulation of endothelial cell migration |
| regulation of endothelial cell apoptotic process |
| regulation of macrophage activation |
| regulation of interleukin-12 production |
| positive regulation of wound healing |
| regulation of megakaryocyte differentiation |
| positive regulation of blood vessel endothelial cell migration |
| regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| negative regulation of chemotaxis |
| sprouting angiogenesis |
| regulation of organic acid transport |
| phosphatidylserine binding |
| regulation of focal adhesion assembly |
| regulation of cell-substrate junction assembly |
| peptide cross-linking |
| negative regulation of cell-substrate adhesion |
| positive regulation of response to wounding |
| negative regulation of epithelial cell migration |
| regulation of protein processing |
| platelet alpha granule lumen |
| positive regulation of cytokine biosynthetic process |
| regulation of adherens junction organization |
| multicellular organismal response to stress |
| regulation of protein maturation |
| regulation of sprouting angiogenesis |
| cellular response to heat |
| regulation of blood coagulation |
| regulation of epithelial cell apoptotic process |
| regulation of hemostasis |
| regulation of coagulation |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of smooth muscle cell proliferation |
| positive regulation of tumor necrosis factor production |
| secretory granule |
| positive regulation of leukocyte chemotaxis |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| regulation of cell junction assembly |
| regulation of blood vessel endothelial cell migration |
| negative regulation of cysteine-type endopeptidase activity |
| positive regulation of reactive oxygen species metabolic process |
| negative regulation of ion transmembrane transport |
| regulation of anion transport |
| positive regulation of endothelial cell migration |
| negative regulation of extrinsic apoptotic signaling pathway |
| negative regulation of angiogenesis |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of cytokine biosynthetic process |
| negative regulation of blood vessel morphogenesis |
| regulation of lipid transport |
| response to heat |
| regulation of leukocyte chemotaxis |
| regulation of transforming growth factor beta receptor signaling pathway |
| regulation of cell-matrix adhesion |
| negative regulation of vasculature development |
| regulation of cellular response to transforming growth factor beta stimulus |
| negative regulation of transmembrane transport |
| negative regulation of epithelial cell proliferation |
| positive regulation of translation |
| positive regulation of leukocyte migration |
| platelet degranulation |
| regulation of endothelial cell proliferation |
| phagocytosis, engulfment |
| integrin binding |
| extracellular matrix structural constituent |
| regulation of smooth muscle cell proliferation |
| positive regulation of chemotaxis |
| regulation of wound healing |
| response to glucose |
| regulation of lipid localization |
| plasma membrane invagination |
| positive regulation of epithelial cell migration |
| response to hexose |
| membrane invagination |
| cell cycle arrest |
| negative regulation of ion transport |
| negative regulation of cellular response to growth factor stimulus |
| response to monosaccharide |
| regulation of tumor necrosis factor production |
| response to calcium ion |
| positive regulation of cellular amide metabolic process |
| regulation of tumor necrosis factor superfamily cytokine production |
| regulation of extrinsic apoptotic signaling pathway |
| activation of MAPK activity |
| regulation of endothelial cell migration |
| response to unfolded protein |
| positive regulation of angiogenesis |
| positive regulation of protein kinase B signaling |
| regulation of response to wounding |
| heparin binding |
| response to carbohydrate |
| positive regulation of apoptotic signaling pathway |
| response to temperature stimulus |
| regulation of reactive oxygen species metabolic process |
| positive regulation of vasculature development |
| response to topologically incorrect protein |
| response to ketone |
| regulation of leukocyte migration |
| regulation of cell-substrate adhesion |
| response to mechanical stimulus |
| regulation of chemotaxis |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of protein kinase B signaling |
| regulation of epithelial cell migration |
| regulation of myeloid cell differentiation |
| negative regulation of apoptotic signaling pathway |
| extracellular matrix |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| cellular response to tumor necrosis factor |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| negative regulation of peptidase activity |
| response to endoplasmic reticulum stress |
| negative regulation of cell migration |
| positive regulation of MAP kinase activity |
| response to tumor necrosis factor |
| regulation of cellular response to growth factor stimulus |
| negative regulation of cell adhesion |
| negative regulation of cytokine production |
| negative regulation of cell motility |
| regulation of angiogenesis |
| endoplasmic reticulum lumen |
| negative regulation of cellular component movement |
| angiogenesis |
| regulation of vasculature development |
| negative regulation of locomotion |
| response to steroid hormone |
| activation of protein kinase activity |
| phagocytosis |
| regulation of epithelial cell proliferation |
| positive regulation of protein serine/threonine kinase activity |
| extracellular matrix organization |
| regulation of MAP kinase activity |
| response to hypoxia |
| regulation of translation |
| negative regulation of proteolysis |
| response to decreased oxygen levels |
| negative regulation of response to external stimulus |
| collagen-containing extracellular matrix |
| response to metal ion |
| response to oxygen levels |
| extracellular structure organization |
| external side of plasma membrane |
| regulation of apoptotic signaling pathway |
| positive regulation of leukocyte activation |
| regulation of cellular amide metabolic process |
| blood vessel morphogenesis |
| positive regulation of cell activation |
| regulation of endopeptidase activity |
| negative regulation of immune system process |
| regulation of peptidase activity |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| negative regulation of hydrolase activity |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| blood vessel development |
| regulation of body fluid levels |
| inflammatory response |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| negative regulation of intracellular signal transduction |
| vasculature development |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| positive regulation of cell motility |
| posttranscriptional regulation of gene expression |
| response to growth factor |
| response to inorganic substance |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| positive regulation of MAPK cascade |
| positive regulation of locomotion |
| endocytosis |
| regulation of transmembrane transport |
| behavior |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| cell surface |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| tube morphogenesis |
| positive regulation of transferase activity |
| import into cell |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| regulation of cytokine production |
| positive regulation of cell death |
| regulation of ion transport |
| regulated exocytosis |
| negative regulation of cellular component organization |
| calcium ion binding |
| regulation of proteolysis |
| regulation of MAPK cascade |
| negative regulation of catalytic activity |
| exocytosis |
| regulation of protein kinase activity |
| tube development |
| regulation of cell migration |
| response to lipid |
| membrane organization |
| circulatory system development |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| cell adhesion |
| biological adhesion |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| cell migration |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| cell cycle process |
| secretion by cell |
| cellular response to cytokine stimulus |
| endoplasmic reticulum |
| positive regulation of protein phosphorylation |
| response to drug |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| export from cell |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| positive regulation of immune system process |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| locomotion |
| cell cycle |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Artemisinin 50μM R08 exp450 | -2.34 |
| Bisphenol F 50μM R08 exp457 | -1.91 |
| Alpha-Amanitin 0.5μM R00 exp5 | -1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8632
- Expression level (log2 read counts): 1.25
Expression Distribution
THBS1 Expression in NALM6 Cells: 1.25
