TIMM10

Entrez Summary: N/A
UniProt Summary: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. {ECO:0000269|PubMed:14726512}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 716/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	28/28
bone	26/26
breast	30/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	19/20
lung	71/75
lymphocyte	15/16
ovary	26/26
pancreas	22/24
peripheral nervous system	16/16
plasma cell	13/15
prostate	0/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	4/5

Expression Distribution

protein transporter activity
mitochondrial intermembrane space protein transporter complex
TIM23 mitochondrial import inner membrane translocase complex
protein insertion into mitochondrial inner membrane
chaperone-mediated protein transport
establishment of protein localization to mitochondrial membrane
protein insertion into mitochondrial membrane
protein insertion into membrane
inner mitochondrial membrane organization
protein targeting to mitochondrion
establishment of protein localization to mitochondrion
protein localization to mitochondrion
mitochondrial intermembrane space
chaperone binding
mitochondrial membrane organization
sensory perception of sound
sensory perception of mechanical stimulus
mitochondrial transport
establishment of protein localization to membrane
protein targeting
mitochondrial inner membrane
establishment of protein localization to organelle
mitochondrion organization
protein localization to membrane
protein localization to organelle
zinc ion binding
membrane organization
protein homodimerization activity
sensory perception
intracellular protein transport
mitochondrion
nervous system process
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell