TIPIN

Entrez Summary: N/A
UniProt Summary: Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. {ECO:0000269|PubMed:17102137, ECO:0000269|PubMed:17116885, ECO:0000269|PubMed:17296725}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.78
AICAR 240μM R05 exp211	-1.75
L-BMAA 500 to 750μM on day4 R04 exp185	1.73
NFN1 1μM R03 exp100	1.76
Nicotinamide 1000μM R03 exp101	1.82

Global Fraction of Cell Lines Where Essential: 91/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	2/28
blood	3/28
bone	6/26
breast	6/33
central nervous system	3/56
cervix	0/4
colorectal	3/17
esophagus	0/13
fibroblast	0/1
gastric	3/16
kidney	3/21
liver	4/20
lung	5/75
lymphocyte	2/16
ovary	4/26
pancreas	4/24
peripheral nervous system	1/16
plasma cell	5/15
prostate	0/1
skin	0/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	3/29
uterus	2/5

Expression Distribution

Gene	Correlation
TWISTNB	0.424
DTL	0.412

replication fork arrest
replication fork protection complex
replication fork protection
intra-S DNA damage checkpoint
DNA replication checkpoint
regulation of nuclear cell cycle DNA replication
negative regulation of DNA-dependent DNA replication
negative regulation of DNA replication
DNA-dependent DNA replication maintenance of fidelity
regulation of DNA-dependent DNA replication
mitotic DNA damage checkpoint
mitotic DNA integrity checkpoint
regulation of DNA replication
DNA-dependent DNA replication
DNA damage checkpoint
response to UV
DNA integrity checkpoint
mitotic cell cycle checkpoint
cell cycle checkpoint
DNA replication
nuclear chromatin
cell cycle phase transition
negative regulation of mitotic cell cycle
response to light stimulus
response to radiation
cell division
negative regulation of cell cycle
mitotic cell cycle process
regulation of mitotic cell cycle
mitotic cell cycle
intracellular membrane-bounded organelle
DNA metabolic process
regulation of cell cycle process
cellular response to DNA damage stimulus
positive regulation of cell population proliferation
cell cycle process
response to abiotic stimulus
regulation of cell cycle
cell cycle
negative regulation of cellular macromolecule biosynthetic process