TK2

Entrez Summary: This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012].
UniProt Summary: Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents. {ECO:0000269|PubMed:11687801}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Clomiphene 4.4μM R02 exp68	-1.99
KU-0063794 3.8μM R02 exp71	-1.73

deoxycytidine metabolic process
nucleoside kinase activity
thymidine kinase activity
deoxycytidine kinase activity
deoxynucleoside kinase activity
thymidine metabolic process
pyrimidine deoxyribonucleoside metabolic process
deoxyribonucleoside metabolic process
deoxyribonucleoside monophosphate biosynthetic process
pyrimidine-containing compound salvage
pyrimidine nucleoside salvage
deoxyribonucleoside monophosphate metabolic process
pyrimidine nucleoside biosynthetic process
nucleoside salvage
cellular metabolic compound salvage
pyrimidine nucleoside metabolic process
nucleoside biosynthetic process
glycosyl compound biosynthetic process
nucleoside monophosphate biosynthetic process
pyrimidine-containing compound biosynthetic process
nucleoside monophosphate metabolic process
nucleobase-containing small molecule biosynthetic process
pyrimidine-containing compound metabolic process
nucleoside metabolic process
DNA biosynthetic process
glycosyl compound metabolic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
mitochondrial matrix
nucleotide metabolic process
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
small molecule biosynthetic process
carbohydrate derivative biosynthetic process
DNA metabolic process
organophosphate metabolic process
carbohydrate derivative metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process