TLR4
Gene Information
- Official Symbol: TLR4
- Official Name: toll like receptor 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 7099
- UniProt: O00206
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| TIR |
| LRR 4 |
GO Terms
| positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway |
| detection of fungus |
| negative regulation of interleukin-23 production |
| nitric oxide production involved in inflammatory response |
| regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway |
| positive regulation of response to macrophage colony-stimulating factor |
| positive regulation of nucleotide-binding oligomerization domain containing signaling pathway |
| positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway |
| positive regulation of cellular response to macrophage colony-stimulating factor stimulus |
| intestinal epithelial structure maintenance |
| detection of lipopolysaccharide |
| positive regulation of platelet activation |
| regulation of cellular response to macrophage colony-stimulating factor stimulus |
| lipopolysaccharide receptor activity |
| lipopolysaccharide receptor complex |
| positive regulation of oxidative stress-induced neuron death |
| regulation of response to macrophage colony-stimulating factor |
| regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway |
| B cell proliferation involved in immune response |
| positive regulation of interleukin-12 biosynthetic process |
| negative regulation of MyD88-independent toll-like receptor signaling pathway |
| positive regulation of interferon-beta biosynthetic process |
| positive regulation of NLRP3 inflammasome complex assembly |
| regulation of interferon-beta biosynthetic process |
| regulation of interleukin-23 production |
| regulation of MyD88-independent toll-like receptor signaling pathway |
| regulation of interleukin-12 biosynthetic process |
| positive regulation of macrophage cytokine production |
| regulation of nucleotide-binding oligomerization domain containing signaling pathway |
| interleukin-1 beta secretion |
| positive regulation of MHC class II biosynthetic process |
| response to lipoteichoic acid |
| cellular response to oxidised low-density lipoprotein particle stimulus |
| cellular response to lipoteichoic acid |
| detection of molecule of bacterial origin |
| interleukin-1 secretion |
| regulation of dendritic cell cytokine production |
| positive regulation of interleukin-8 biosynthetic process |
| I-kappaB phosphorylation |
| detection of other organism |
| regulation of MHC class II biosynthetic process |
| negative regulation of interleukin-17 production |
| regulation of macrophage cytokine production |
| interleukin-1 beta production |
| regulation of NLRP3 inflammasome complex assembly |
| positive regulation of nitric-oxide synthase biosynthetic process |
| positive regulation of oxidative stress-induced cell death |
| interleukin-1 production |
| production of molecular mediator involved in inflammatory response |
| regulation of interleukin-8 biosynthetic process |
| positive regulation of cellular response to oxidative stress |
| positive regulation of cytokine production involved in inflammatory response |
| regulation of nitric-oxide synthase biosynthetic process |
| positive regulation of myeloid leukocyte cytokine production involved in immune response |
| T-helper 1 type immune response |
| positive regulation of response to oxidative stress |
| toll-like receptor 4 signaling pathway |
| maintenance of gastrointestinal epithelium |
| interferon-gamma production |
| detection of external biotic stimulus |
| positive regulation of tumor necrosis factor biosynthetic process |
| detection of biotic stimulus |
| necroptotic process |
| positive regulation of interferon-alpha production |
| positive regulation of macrophage activation |
| regulation of oxidative stress-induced neuron death |
| positive regulation of hemostasis |
| positive regulation of blood coagulation |
| negative regulation of osteoclast differentiation |
| positive regulation of coagulation |
| response to lipoprotein particle |
| epithelial structure maintenance |
| phagocytic cup |
| programmed necrotic cell death |
| cellular response to lipoprotein particle stimulus |
| regulation of interferon-alpha production |
| TRIF-dependent toll-like receptor signaling pathway |
| regulation of interleukin-17 production |
| regulation of tumor necrosis factor biosynthetic process |
| necrotic cell death |
| positive regulation of interferon-beta production |
| regulation of platelet activation |
| MyD88-dependent toll-like receptor signaling pathway |
| MyD88-independent toll-like receptor signaling pathway |
| negative regulation of interferon-gamma production |
| positive regulation of interleukin-1 beta secretion |
| lipopolysaccharide-mediated signaling pathway |
| positive regulation of interleukin-12 production |
| lipopolysaccharide binding |
| positive regulation of interleukin-10 production |
| astrocyte development |
| intrinsic component of plasma membrane |
| positive regulation of interleukin-1 secretion |
| negative regulation of toll-like receptor signaling pathway |
| cellular response to amyloid-beta |
| positive regulation of nitric oxide biosynthetic process |
| regulation of cytokine production involved in inflammatory response |
| positive regulation of nitric oxide metabolic process |
| B cell proliferation |
| positive regulation of B cell proliferation |
| negative regulation of interleukin-6 production |
| B cell activation involved in immune response |
| negative regulation of myeloid leukocyte differentiation |
| regulation of interleukin-1 beta secretion |
| negative regulation of cold-induced thermogenesis |
| cytokine secretion |
| regulation of interferon-beta production |
| positive regulation of interleukin-8 production |
| response to fungus |
| response to amyloid-beta |
| positive regulation of reactive oxygen species biosynthetic process |
| macrophage activation |
| positive regulation of interleukin-1 beta production |
| regulation of interleukin-10 production |
| regulation of macrophage activation |
| astrocyte differentiation |
| positive regulation of cytokine production involved in immune response |
| regulation of interleukin-12 production |
| positive regulation of wound healing |
| regulation of interleukin-1 secretion |
| positive regulation of chemokine production |
| regulation of nitric oxide biosynthetic process |
| positive regulation of response to cytokine stimulus |
| positive regulation of interleukin-1 production |
| negative regulation of tumor necrosis factor production |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| regulation of B cell proliferation |
| regulation of oxidative stress-induced cell death |
| positive regulation of interferon-gamma production |
| positive regulation of response to wounding |
| regulation of osteoclast differentiation |
| negative regulation of ERK1 and ERK2 cascade |
| positive regulation of cytokine biosynthetic process |
| regulation of toll-like receptor signaling pathway |
| regulation of interleukin-8 production |
| I-kappaB kinase/NF-kappaB signaling |
| digestive system process |
| regulation of cellular response to oxidative stress |
| negative regulation of myeloid cell differentiation |
| positive regulation of NIK/NF-kappaB signaling |
| positive regulation of type I interferon production |
| regulation of chemokine production |
| regulation of blood coagulation |
| cellular response to mechanical stimulus |
| regulation of hemostasis |
| amyloid-beta binding |
| regulation of interleukin-1 beta production |
| regulation of coagulation |
| defense response to Gram-negative bacterium |
| lymphocyte proliferation |
| regulation of response to oxidative stress |
| regulation of cytokine production involved in immune response |
| regulation of reactive oxygen species biosynthetic process |
| mononuclear cell proliferation |
| positive regulation of tumor necrosis factor production |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of neuron death |
| regulation of interleukin-1 production |
| positive regulation of interleukin-6 production |
| positive regulation of reactive oxygen species metabolic process |
| positive regulation of production of molecular mediator of immune response |
| leukocyte proliferation |
| toll-like receptor signaling pathway |
| regulation of interferon-gamma production |
| negative regulation of leukocyte differentiation |
| regulation of cytokine biosynthetic process |
| glial cell development |
| regulation of NIK/NF-kappaB signaling |
| lymphocyte activation involved in immune response |
| digestion |
| regulation of myeloid leukocyte differentiation |
| regulation of type I interferon production |
| pattern recognition receptor signaling pathway |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte proliferation |
| transmembrane signaling receptor activity |
| negative regulation of hemopoiesis |
| regulation of wound healing |
| positive regulation of inflammatory response |
| positive regulation of JNK cascade |
| positive regulation of cytokine secretion |
| regulation of interleukin-6 production |
| regulation of production of molecular mediator of immune response |
| regulation of cold-induced thermogenesis |
| regulation of tumor necrosis factor production |
| cytokine production |
| regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of NF-kappaB transcription factor activity |
| B cell activation |
| activation of MAPK activity |
| protein secretion |
| establishment of protein localization to extracellular region |
| cellular response to interferon-gamma |
| protein localization to extracellular region |
| regulation of response to wounding |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of B cell activation |
| negative regulation of MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| glial cell differentiation |
| peptide secretion |
| regulation of response to cytokine stimulus |
| regulation of reactive oxygen species metabolic process |
| response to interferon-gamma |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| cellular response to lipopolysaccharide |
| regulation of JNK cascade |
| tissue homeostasis |
| cellular response to molecule of bacterial origin |
| signaling receptor activity |
| regulation of cytokine secretion |
| receptor complex |
| regulation of leukocyte mediated immunity |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| positive regulation of ERK1 and ERK2 cascade |
| endosome membrane |
| response to mechanical stimulus |
| gliogenesis |
| cellular response to biotic stimulus |
| positive regulation of immune effector process |
| regulation of leukocyte proliferation |
| regulation of myeloid cell differentiation |
| innate immune response-activating signal transduction |
| regulation of stress-activated MAPK cascade |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of stress-activated protein kinase signaling cascade |
| positive regulation of protein complex assembly |
| early endosome |
| activation of innate immune response |
| positive regulation of DNA-binding transcription factor activity |
| positive regulation of MAP kinase activity |
| positive regulation of protein secretion |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| apoptotic signaling pathway |
| positive regulation of peptide secretion |
| regulation of ERK1 and ERK2 cascade |
| regulation of neuron death |
| response to lipopolysaccharide |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| multicellular organismal homeostasis |
| cellular response to peptide |
| response to molecule of bacterial origin |
| activation of protein kinase activity |
| phagocytosis |
| defense response to bacterium |
| signaling receptor binding |
| cellular response to external stimulus |
| regulation of inflammatory response |
| positive regulation of protein serine/threonine kinase activity |
| anatomical structure homeostasis |
| positive regulation of innate immune response |
| regulation of MAP kinase activity |
| regulation of neurotransmitter levels |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| lymphocyte activation |
| external side of plasma membrane |
| positive regulation of leukocyte activation |
| positive regulation of secretion by cell |
| negative regulation of protein phosphorylation |
| positive regulation of cell activation |
| positive regulation of protein transport |
| regulation of DNA-binding transcription factor activity |
| positive regulation of secretion |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of protein complex assembly |
| regulation of innate immune response |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of immune effector process |
| response to peptide |
| positive regulation of defense response |
| protein heterodimerization activity |
| regulation of peptide secretion |
| regulation of body fluid levels |
| inflammatory response |
| negative regulation of intracellular signal transduction |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| cellular response to lipid |
| positive regulation of cellular component biogenesis |
| regulation of response to biotic stimulus |
| detection of chemical stimulus |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| cell population proliferation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| immune response-activating signal transduction |
| positive regulation of kinase activity |
| myeloid leukocyte activation |
| negative regulation of protein modification process |
| immune response-regulating signaling pathway |
| cellular response to organonitrogen compound |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| adaptive immune response |
| cell surface |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| activation of immune response |
| regulation of cell activation |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| detection of stimulus |
| response to bacterium |
| regulation of cytokine production |
| positive regulation of cell death |
| perinuclear region of cytoplasm |
| regulation of protein transport |
| negative regulation of cell differentiation |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| regulation of protein kinase activity |
| regulation of secretion |
| response to lipid |
| positive regulation of immune response |
| regulation of kinase activity |
| positive regulation of cell population proliferation |
| apoptotic process |
| leukocyte activation |
| negative regulation of developmental process |
| defense response to other organism |
| regulation of cellular component biogenesis |
| protein phosphorylation |
| regulation of transferase activity |
| central nervous system development |
| positive regulation of transport |
| response to organonitrogen compound |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| export from cell |
| programmed cell death |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| identical protein binding |
| cell activation |
| response to nitrogen compound |
| cell death |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| phosphorylation |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| protein transport |
| peptide transport |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| amide transport |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| nitrogen compound transport |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| vesicle-mediated transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Pterostilbene 16μM R02 exp78 | -1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14391
- Expression level (log2 read counts): 3.81
Expression Distribution
TLR4 Expression in NALM6 Cells: 3.81
