TMBIM1

Gene Information

Official Symbol: TMBIM1
Official Name: transmembrane BAX inhibitor motif containing 1
Aliases and Previous Symbols: N/A
Entrez ID: 64114
UniProt: Q969X1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16365
Expression level (log2 read counts): 1.89

Expression Distribution

Screen	Score
All-trans-Retinoic-Acid 8μM R07 exp333	-1.74
JQ1 0.01μM R03 exp130	1.7

negative regulation of Fas signaling pathway
regulation of Fas signaling pathway
positive regulation of blood vessel remodeling
regulation of blood vessel remodeling
death receptor binding
negative regulation of protein localization to plasma membrane
negative regulation of protein localization to cell periphery
negative regulation of protein localization to membrane
positive regulation of tissue remodeling
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of tissue remodeling
specific granule membrane
regulation of protein localization to plasma membrane
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of cellular protein localization
regulation of protein localization to cell periphery
regulation of extrinsic apoptotic signaling pathway
regulation of protein localization to membrane
endosome membrane
negative regulation of apoptotic signaling pathway
lysosomal membrane
regulation of apoptotic signaling pathway
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
regulation of cellular protein localization
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
intracellular membrane-bounded organelle
regulated exocytosis
leukocyte mediated immunity
negative regulation of catalytic activity
exocytosis