TMEM135

Entrez Summary: N/A
UniProt Summary: Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization. {ECO:0000250|UniProtKB:Q5U4F4, ECO:0000250|UniProtKB:Q9CYV5}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CHIR-124 0.04μM R06 exp272	-2.53
Epigallocatechin gallate 20μM R05 exp230	1.75
Cabazitaxel 0.001μM R05 exp223	1.83
Tanespimycin 14μM R08 exp527	1.85
Deguelin 0.15μM R05 exp209	1.92
Ibrutinib 1μM R07 exp372	1.92
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.94
Etoposide 0.1μM R05 exp198	2
UM0011500 10μM R05 exp246	2.03
Hypoxia 5%O2 R04 exp191	2.32

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

response to food
regulation of mitochondrial fission
response to cold
peroxisomal membrane
peroxisome organization
lipid droplet
mitochondrial membrane
peroxisome
response to temperature stimulus
regulation of mitochondrion organization
response to nutrient levels
response to extracellular stimulus
regulation of anatomical structure morphogenesis
response to abiotic stimulus
regulation of organelle organization