TMEM161A

Gene Information

Official Symbol: TMEM161A
Official Name: transmembrane protein 161A
Aliases and Previous Symbols: N/A
Entrez ID: 54929
UniProt: Q9NX61
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. {ECO:0000269|PubMed:16551573}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3100
Expression level (log2 read counts): 5.52

Expression Distribution

Screen	Score
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.77
Epigallocatechin gallate 20μM R05 exp230	1.79

Gene	Correlation
PRIM1	0.55
POLR2J3	0.401

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
regulation of intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of DNA repair
negative regulation of response to DNA damage stimulus
cellular response to UV
negative regulation of intrinsic apoptotic signaling pathway
positive regulation of response to DNA damage stimulus
response to retinoic acid
cellular response to light stimulus
regulation of DNA repair
response to UV
regulation of intrinsic apoptotic signaling pathway
cellular response to radiation
positive regulation of DNA metabolic process
regulation of response to DNA damage stimulus
negative regulation of apoptotic signaling pathway
cellular response to oxidative stress
response to light stimulus
cellular response to abiotic stimulus
cellular response to environmental stimulus
response to acid chemical
regulation of DNA metabolic process
response to oxidative stress
regulation of apoptotic signaling pathway
response to radiation
negative regulation of intracellular signal transduction
regulation of cellular response to stress
response to lipid
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
response to abiotic stimulus
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of response to stress
regulation of apoptotic process
response to oxygen-containing compound
regulation of programmed cell death
negative regulation of response to stimulus