TMEM27

Gene Information

Official Symbol: CLTRN
Official Name: collectrin, amino acid transport regulator
Aliases and Previous Symbols: N/A
Entrez ID: 57393
UniProt: Q9HBJ8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013].
UniProt Summary: Regulator of SNARE complex function. Stimulator of beta cell replication. {ECO:0000269|PubMed:16330323}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17758
Expression level (log2 read counts): -5.01

Expression Distribution

positive regulation of SNARE complex assembly
positive regulation of vesicle fusion
regulation of SNARE complex assembly
positive regulation of calcium ion-dependent exocytosis
regulation of vesicle fusion
positive regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of calcium ion-dependent exocytosis
positive regulation of regulated secretory pathway
regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of insulin secretion
positive regulation of exocytosis
positive regulation of peptide hormone secretion
positive regulation of hormone secretion
regulation of regulated secretory pathway
regulation of insulin secretion
regulation of peptide hormone secretion
regulation of exocytosis
positive regulation of protein complex assembly
regulation of hormone secretion
positive regulation of protein secretion
positive regulation of peptide secretion
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
regulation of protein complex assembly
positive regulation of establishment of protein localization
regulation of protein secretion
regulation of peptide secretion
positive regulation of cellular component biogenesis
regulation of hormone levels
regulation of vesicle-mediated transport
positive regulation of organelle organization
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
regulation of secretion
protein homodimerization activity
regulation of cellular localization
regulation of cellular component biogenesis