TMEM30B

Entrez Summary: N/A
UniProt Summary: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane. {ECO:0000269|PubMed:20961850, ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
42°C R08 exp539	1.72
PU-H71 1μM R08 exp515	1.86

aminophospholipid flippase activity
aminophospholipid translocation
aminophospholipid transport
positive regulation of protein exit from endoplasmic reticulum
ATPase-coupled intramembrane lipid transporter activity
regulation of protein exit from endoplasmic reticulum
phospholipid translocation
lipid translocation
regulation of membrane lipid distribution
phospholipid transport
organophosphate ester transport
positive regulation of intracellular protein transport
positive regulation of intracellular transport
regulation of intracellular protein transport
lipid transport
lipid localization
positive regulation of cellular protein localization
regulation of intracellular transport
positive regulation of protein transport
organic anion transport
positive regulation of establishment of protein localization
regulation of cellular protein localization
anion transport
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
membrane organization
regulation of cellular localization
Golgi apparatus
positive regulation of transport
endoplasmic reticulum
regulation of protein localization
ion transport
nitrogen compound transport
regulation of transport