TMIGD2

Gene Information

Official Symbol: TMIGD2
Official Name: transmembrane and immunoglobulin domain containing 2
Aliases and Previous Symbols: N/A
Entrez ID: 126259
UniProt: Q96BF3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T- cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:22419821, ECO:0000269|PubMed:23784006}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16478
Expression level (log2 read counts): 0.87

Expression Distribution

positive regulation of activated T cell proliferation
coreceptor activity
regulation of activated T cell proliferation
T cell costimulation
lymphocyte costimulation
positive regulation of T cell proliferation
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
positive regulation of leukocyte proliferation
immunoglobulin production
regulation of T cell proliferation
positive regulation of angiogenesis
production of molecular mediator of immune response
positive regulation of vasculature development
positive regulation of T cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
positive regulation of leukocyte cell-cell adhesion
regulation of leukocyte proliferation
positive regulation of cell-cell adhesion
regulation of angiogenesis
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
regulation of vasculature development
positive regulation of lymphocyte activation
regulation of cell-cell adhesion
positive regulation of leukocyte activation
positive regulation of cell adhesion
positive regulation of cell activation
positive regulation of cytokine production
regulation of lymphocyte activation
regulation of leukocyte activation
regulation of cell activation
regulation of cell adhesion
regulation of cytokine production
positive regulation of cell population proliferation
regulation of anatomical structure morphogenesis
positive regulation of immune system process
positive regulation of developmental process
extracellular space