TNFSF15

Gene Information

Official Symbol: TNFSF15
Official Name: TNF superfamily member 15
Aliases and Previous Symbols: N/A
Entrez ID: 9966
UniProt: O95150
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
UniProt Summary: Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. {ECO:0000269|PubMed:10597252, ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:9872942}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14359
Expression level (log2 read counts): 2.28

Expression Distribution

Screen	Score
RO-3307 4.7μM R02 exp80	-1.8
Resminostat 0.5μM R07 exp393	1.91
I-BRD9 4μM R07 exp365	2.25

cytokine metabolic process
activation of NF-kappaB-inducing kinase activity
tumor necrosis factor receptor binding
positive regulation of NIK/NF-kappaB signaling
NIK/NF-kappaB signaling
activation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of NIK/NF-kappaB signaling
tumor necrosis factor-mediated signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity
positive regulation of endopeptidase activity
cytokine activity
positive regulation of peptidase activity
regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to tumor necrosis factor
regulation of cysteine-type endopeptidase activity
response to tumor necrosis factor
activation of protein kinase activity
signaling receptor binding
positive regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
positive regulation of protein kinase activity
positive regulation of kinase activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of transferase activity
cytokine-mediated signaling pathway
positive regulation of cell death
regulation of proteolysis
positive regulation of hydrolase activity
regulation of protein kinase activity
regulation of kinase activity
apoptotic process
regulation of transferase activity
cellular response to cytokine stimulus
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
programmed cell death
positive regulation of phosphorylation