TOR1AIP1

Entrez Summary: This gene encodes a type 2 integral membrane protein that binds A- and B-type lamins. The encoded protein localizes to the inner nuclear membrane and may be involved in maintaining the attachment of the nuclear membrane to the nuclear lamina during cell division. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Citral 75μM R06 exp275	1.74
ABT-702 0.1μM R06 exp260	1.96

nuclear membrane organization
protein localization to nuclear envelope
lamin binding
ATPase activator activity
nuclear inner membrane
nuclear envelope organization
positive regulation of ATPase activity
cytoskeletal protein binding
ATPase binding
regulation of ATPase activity
nucleus organization
protein localization to nucleus
nuclear membrane
endomembrane system organization
protein localization to organelle
positive regulation of hydrolase activity
membrane organization
regulation of hydrolase activity
positive regulation of catalytic activity
cellular protein localization
cellular macromolecule localization
positive regulation of molecular function