TP53INP2

Entrez Summary: N/A
UniProt Summary: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. {ECO:0000269|PubMed:18030323, ECO:0000269|PubMed:19056683, ECO:0000269|PubMed:22470510}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Docetaxel 0.002μM R01 exp45	-2.41
Artemisinin 50μM R08 exp450	-1.72

autophagosome assembly
autophagosome organization
autophagosome
ubiquitin binding
PML body
negative regulation of cellular protein localization
positive regulation of autophagy
osteoblast differentiation
vacuole organization
macroautophagy
tissue homeostasis
cytoplasmic vesicle
ossification
autophagy
process utilizing autophagic mechanism
multicellular organismal homeostasis
regulation of autophagy
anatomical structure homeostasis
positive regulation of cellular catabolic process
positive regulation of catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
regulation of cellular protein localization
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
organelle assembly
regulation of cellular catabolic process
cellular macromolecule catabolic process
regulation of cellular localization
regulation of catabolic process
regulation of protein localization
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
homeostatic process