TPCN2

Entrez Summary: This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009].
UniProt Summary: Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. {ECO:0000269|PubMed:19387438, ECO:0000269|PubMed:19620632}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

NAADP-sensitive calcium-release channel activity
voltage-gated calcium channel activity
smooth muscle contraction
release of sequestered calcium ion into cytosol
negative regulation of sequestering of calcium ion
lytic vacuole organization
lysosome organization
calcium ion transmembrane import into cytosol
calcium ion transport into cytosol
cytosolic calcium ion transport
regulation of sequestering of calcium ion
vacuole organization
calcium-mediated signaling
calcium ion transmembrane transport
endosome membrane
calcium ion transport
muscle contraction
lysosome
positive regulation of cytosolic calcium ion concentration
divalent metal ion transport
muscle system process
lysosomal membrane
divalent inorganic cation transport
regulation of cytosolic calcium ion concentration
regulation of autophagy
second-messenger-mediated signaling
cellular calcium ion homeostasis
calcium ion homeostasis
protein kinase binding
cellular divalent inorganic cation homeostasis
regulation of ion transmembrane transport
divalent inorganic cation homeostasis
cellular metal ion homeostasis
inorganic cation transmembrane transport
regulation of transmembrane transport
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis