TRAM1L1

Entrez Summary: N/A
UniProt Summary: Stimulatory or required for the translocation of secretory proteins across the ER membrane. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.99
Taxol 0.004μM R03 exp103	-1.79
UM0125461 0.74μM R02 exp84	1.8

TRAM LAG1 CLN8
TRAM1

SRP-dependent cotranslational protein targeting to membrane, translocation
intracellular protein transmembrane transport
protein transmembrane transport
rough endoplasmic reticulum
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
protein localization to endoplasmic reticulum
protein targeting to membrane
establishment of protein localization to membrane
protein targeting
establishment of protein localization to organelle
protein localization to membrane
protein localization to organelle
endoplasmic reticulum membrane
intracellular protein transport
transmembrane transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport